Unexplained male infertility

To highlight the concept of unexplained male infertility and discuss the potential causes and its proper management.

Review of literature.

Male infertility of unknown origin is a condition in which fertility impairment occurs spontaneously or due to an obscure or unknown cause. It includes two categories, unexplained male infertility and idiopathic male infertility. The dividing line between them is semen analysis, which is normal in the unexplained category and abnormal in idiopathic infertility. After ruling out female infertility factors, erectile problems and coital factors, modern andrology may help to analyze the unexplained male fertility problem on the basis of cellular and subcellular mechanisms. Furthermore, this analysis may lead to the selection of proper treatment options fitting the needs of patients with unexplained infertility.

Despite the advances and innovation of sophisticated laboratory tests in the field of andrology, further research is still needed to solve the dilemma of infertility.